Biochemistry & Enzymes

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Enzymes A-Z

Complete database of 6965 enzymes with EC numbers, catalytic activities, alternative names, and UniProt cross-references. Browse by EC class or search for specific enzymes.

Enzymes A-Z

Complete database of 6965 enzymes with EC numbers, catalytic activities, alternative names, and UniProt cross-references. Browse by EC class or search for specific enzymes.

hercynylcysteine S-oxide lyase (EC 4.4.1.36)

hercynylcysteine S-oxide lyase. EC 4.4.1.36.. S-(hercyn-2-yl)-L-cysteine S-oxide + AH2 + H(+) = ergothioneine +

hercynylcysteine S-oxide synthase (EC 1.21.3.10)

hercynylcysteine S-oxide synthase. EC 1.21.3.10.. hercynine + L-cysteine + O2 = S-(hercyn-2-yl)-L-cysteine S-oxide + H2O.

hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase (EC 3.2.1.168)

hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase. EC 3.2.1.168.. (2S)-hesperidin + H2O = rutinose + (2S)-hesperetin.

heteroglycan alpha-mannosyltransferase (EC 2.4.1.48)

heteroglycan alpha-mannosyltransferase. EC 2.4.1.48.. GDP-mannose + heteroglycan = GDP + 2(or 3)-alpha-D-mannosyl-heteroglycan.

heterotrimeric G-protein GTPase (EC 3.6.5.1)

heterotrimeric G-protein GTPase. EC 3.6.5.1.. GTP + H2O = GDP + phosphate + H(+).

hex-5-enoyl-[acyl-carrier protein] acetylenase (EC 1.14.19.40)

hex-5-enoyl-[acyl-carrier protein] acetylenase. EC 1.14.19.40.. 5-hexenoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) =

hexadecanal dehydrogenase (acylating) (EC 1.2.1.42)

hexadecanal dehydrogenase (acylating). EC 1.2.1.42.. hexadecanal + NAD(+) + CoA = hexadecanoyl-CoA + NADH + H(+).

hexadecanol dehydrogenase (EC 1.1.1.164)

hexadecanol dehydrogenase. EC 1.1.1.164.. hexadecan-1-ol + NAD(+) = hexadecanal + NADH + H(+).

hexahomomethionine N-hydroxylase (EC 1.14.13.n6)

hexahomomethionine N-hydroxylase. EC 1.14.13.n6.. (1) hexahomomethionine + 2 O2 + 2 NADPH + 2 H(+) =

hexaprenyl diphosphate synthase (prenyl-diphosphate specific) (EC 2.5.1.158)

hexaprenyl diphosphate synthase (prenyl-diphosphate specific). EC 2.5.1.158.. 5 isopentenyl diphosphate + dimethylallyl diphosphate = all-trans-

hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] (EC 2.5.1.82)

hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]. EC 2.5.1.82.. 2 isopentenyl diphosphate + (2E,6E,10E)-geranylgeranyl diphosphate = all-

hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] (EC 2.5.1.83)

hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]. EC 2.5.1.83.. 3 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-

hexokinase (EC 2.7.1.1)

hexokinase. EC 2.7.1.1.. a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+).

hexose oxidase (EC 1.1.3.5)

hexose oxidase. EC 1.1.3.5.. beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2.

high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.197)

high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase. EC 2.4.1.197.. Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-

hippurate hydrolase (EC 3.5.1.32)

hippurate hydrolase. EC 3.5.1.32.. N-benzoylglycine + H2O = benzoate + glycine.

histamine N-methyltransferase (EC 2.1.1.8)

histamine N-methyltransferase. EC 2.1.1.8.. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine +

histidine ammonia-lyase (EC 4.3.1.3)

histidine ammonia-lyase. EC 4.3.1.3.. L-histidine = trans-urocanate + NH4(+).

histidine decarboxylase (EC 4.1.1.22)

histidine decarboxylase. EC 4.1.1.22.. L-histidine + H(+) = histamine + CO2.

histidine kinase (EC 2.7.13.3)

histidine kinase. EC 2.7.13.3.. ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

histidine N-acetyltransferase (EC 2.3.1.33)

histidine N-acetyltransferase. EC 2.3.1.33.. L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H(+).

histidine racemase (EC 5.1.1.24)

histidine racemase. EC 5.1.1.24.. L-histidine = D-histidine.

histidine transaminase (EC 2.6.1.38)

histidine transaminase. EC 2.6.1.38.. L-histidine + 2-oxoglutarate = 3-(imidazol-5-yl)pyruvate + L-glutamate.

histidine--tRNA ligase (EC 6.1.1.21)

histidine--tRNA ligase. EC 6.1.1.21.. tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate

histidinol dehydrogenase (EC 1.1.1.23)

histidinol dehydrogenase. EC 1.1.1.23.. L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+).

histidinol-phosphatase (EC 3.1.3.15)

histidinol-phosphatase. EC 3.1.3.15.. L-histidinol phosphate + H2O = L-histidinol + phosphate.

histidinol-phosphate transaminase (EC 2.6.1.9)

histidinol-phosphate transaminase. EC 2.6.1.9.. L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl

histolysain (EC 3.4.22.35)

histolysain. EC 3.4.22.35.. Hydrolysis of proteins, including basement membrane collagen and

histone acetyltransferase (EC 2.3.1.48)

histone acetyltransferase. EC 2.3.1.48.. L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA +

histone deacetylase (EC 3.5.1.98)

histone deacetylase. EC 3.5.1.98.. N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate.

HIV-1 retropepsin (EC 3.4.23.16)

HIV-1 retropepsin. EC 3.4.23.16.. Specific for a P1 residue that is hydrophobic, and P1' variable,

HIV-2 retropepsin (EC 3.4.23.47)

HIV-2 retropepsin. EC 3.4.23.47.. Endopeptidase for which the P1 residue is preferably hydrophobic.

holo-[acyl-carrier-protein] synthase (EC 2.7.8.7)

holo-[acyl-carrier-protein] synthase. EC 2.7.8.7.. apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+).

holocytochrome-c synthase (EC 4.4.1.17)

holocytochrome-c synthase. EC 4.4.1.17.. holo-[cytochrome c] = apo-[cytochrome c] + heme b.

homoaconitate hydratase (EC 4.2.1.36)

homoaconitate hydratase. EC 4.2.1.36.. (2R,3S)-homoisocitrate = cis-homoaconitate + H2O.

homocitrate synthase (EC 2.3.3.14)

homocitrate synthase. EC 2.3.3.14.. acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+).

homocysteine desulfhydrase (EC 4.4.1.2)

homocysteine desulfhydrase. EC 4.4.1.2.. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+).

homocysteine S-methyltransferase (EC 2.1.1.10)

homocysteine S-methyltransferase. EC 2.1.1.10.. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+).

homogentisate 1,2-dioxygenase (EC 1.13.11.5)

homogentisate 1,2-dioxygenase. EC 1.13.11.5.. homogentisate + O2 = 4-maleylacetoacetate + H(+).

homogentisate geranylgeranyltransferase (EC 2.5.1.116)

homogentisate geranylgeranyltransferase. EC 2.5.1.116.. homogentisate + (2E,6E,10E)-geranylgeranyl diphosphate + H(+) =

homogentisate phytyltransferase (EC 2.5.1.115)

homogentisate phytyltransferase. EC 2.5.1.115.. phytyl diphosphate + homogentisate + H(+) = 2-methyl-6-phytyl-1,4-

homogentisate solanesyltransferase (EC 2.5.1.117)

homogentisate solanesyltransferase. EC 2.5.1.117.. all-trans-nonaprenyl diphosphate + homogentisate + H(+) = 2-methyl-6-

homoglutathione synthase (EC 6.3.2.23)

homoglutathione synthase. EC 6.3.2.23.. gamma-L-glutamyl-L-cysteine + beta-alanine + ATP = gamma-L-glutamyl-L-

homoisocitrate dehydrogenase (EC 1.1.1.87)

homoisocitrate dehydrogenase. EC 1.1.1.87.. (2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH.

homomethionine N-monooxygenase (EC 1.14.14.42)

homomethionine N-monooxygenase. EC 1.14.14.42.. an L-polyhomomethionine + 2 reduced [NADPH--hemoprotein reductase] + 2 O2

homoserine dehydrogenase (EC 1.1.1.3)

homoserine dehydrogenase. EC 1.1.1.3.. (1) L-homoserine + NAD(+) = L-aspartate 4-semialdehyde + NADH + H(+).

homoserine kinase (EC 2.7.1.39)

homoserine kinase. EC 2.7.1.39.. L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+).

homoserine O-acetyltransferase (EC 2.3.1.31)

homoserine O-acetyltransferase. EC 2.3.1.31.. L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA.

homoserine O-succinyltransferase (EC 2.3.1.46)

homoserine O-succinyltransferase. EC 2.3.1.46.. L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA.

homospermidine oxidase (EC 1.4.3.27)

homospermidine oxidase. EC 1.4.3.27.. sym-homospermidine + 2 O2 + H2O = 1-formylpyrrolizidine + 2 H2O2 +

homospermidine synthase (EC 2.5.1.44)

homospermidine synthase. EC 2.5.1.44.. (1) 2 putrescine = sym-homospermidine + NH4(+).

homospermidine synthase (spermidine-specific) (EC 2.5.1.45)

homospermidine synthase (spermidine-specific). EC 2.5.1.45.. putrescine + spermidine = sym-homospermidine + propane-1,3-diamine.

hormone-sensitive lipase (EC 3.1.1.79)

hormone-sensitive lipase. EC 3.1.1.79.. (1) a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+).

horrilysin (EC 3.4.24.47)

horrilysin. EC 3.4.24.47.. Cleavage of only the single bond 14-Ala-|-Leu-15 in the insulin B chain,

HslU--HslV peptidase (EC 3.4.25.2)

HslU--HslV peptidase. EC 3.4.25.2.. ATP-dependent cleavage of peptide bonds with broad specificity.

HtrA2 peptidase (EC 3.4.21.108)

HtrA2 peptidase. EC 3.4.21.108.. Cleavage of non-polar aliphatic amino-acids at the P1 position, with a

human endogenous retrovirus K endopeptidase (EC 3.4.23.50)

human endogenous retrovirus K endopeptidase. EC 3.4.23.50.. Processing at the authentic HIV-1 PR recognition site and release of the

hyaluronan synthase (EC 2.4.1.212)

hyaluronan synthase. EC 2.4.1.212.. (1) [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-

hyaluronate lyase (EC 4.2.2.1)

hyaluronate lyase. EC 4.2.2.1.. [hyaluronan](n) = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-

hyaluronoglucosaminidase (EC 3.2.1.35)

hyaluronoglucosaminidase. EC 3.2.1.35.. Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine